Atrial stimulation protocols to test inducibility of atrial fibrillation

Abstract Funding Acknowledgements Type of funding sources: None. Background The electrophysiological inducibility atrial fibrillation (AF) after pulmonary vein isolation (PVI) has been identified as a predictor future AF recurrence. Stimulation protocols have not sufficiently studied prospectively with respect to their reliability for inducing AF. Methods and results We conducted prospective monocentric randomized clinical trial evaluate different standardized electrical stimulation on potential induce Patients symptomatic presenting in sinus rhythm scheduled PVI were enrolled. primary outcome was induction A total 30 patients (age=62±2 years, 17% female, 13% persistent AF, left systolic volume (LASV) 93±5 ml) enrolled randomized. To one three performed at the beginning PVI. Atrial induced 4 out 10 (40%) fixed cycle length followed by up 3 extrastimuli (protocol A), 6 (60%) burst B) 9 (90%) using shortest 1:1 capture C), respectively. Time from start significantly lower protocol C vs. B (29±10 sec vs 40±14 366±71 sec; p<0.0001). Isoprenaline used 10% A, 40% 80% C. Overall, there no significant differences concerning age (61±3 63±4 years; p=0.74), LASV (93±6 94±8 ml; p=0.98) or other parameters between inducible non-inducible Conclusion With systematic can be 90%. Further studies are warranted assess specifity these stimulations.